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AddictoQuiz

Benzodiazepines

Benzodiazepines are among the most widely prescribed psychotropic drugs worldwide. They play an important role in the treatment of acute anxiety, insomnia, seizures, withdrawal syndromes, and catatonia. At the same time, their use is associated with well-documented risks: tolerance, dependence, withdrawal, paradoxical reactions, cognitive impairment, falls, and increased accident risk.

This quiz module is designed to test your knowledge of the pharmacology, clinical applications, risks, and safe prescribing principles of benzodiazepines. Questions cover topics ranging from receptor subtypes and pharmacokinetics to epidemiology, deprescribing, and guideline recommendations such as the Beers Criteria.

This section provides a selection of diverse resources intended to support your preparation for and completion of the quiz. The materials may include scientific articles, official reports, practice guidelines, and other relevant documents offering complementary perspectives. Engaging with these resources prior to or during the quiz will help you deepen your understanding of the subject matter, strengthen your analytical approach, and enhance the overall quality of your learning process.

Benzodiazepine Misuse: An Epidemic Within a Pandemic

Sarangi A, McMahon T, Gude J. Cureus. 2021;13(6):e15816.

Management of benzodiazepine misuse and dependence

Brett J, Murnion B. Aust Prescr. 2015;38:152-155.

Brief interventions targeting long-term benzodiazepine and Z-drug use in primary care: a systematic review and meta-analysis

Lynch T, Ryan C, Hughes CM, Presseau J, van Allen ZM, Bradley CP, et al. Addiction. 2020;115:1618-1639.

Benzodiazepine high-doses: The need for an accurate definition

Cloos JM, Lim Cow CYS, Bocquet V. Int J Methods Psychiatr Res. 2021;30:e1888.

Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users

Baandrup L, Ebdrup BH, Rasmussen JØ, Lindschou J, Gluud C, Glenthøj BY. Cochrane Database Syst Rev. 2018;3:CD011481.

The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis

Liu L, Jia L, Jian P, Zhou Y, Zhou J, Wu F, et al. Front Psychiatry. 2020;11:755.

A Systematic Review of Opioid and Benzodiazepine Misuse in Older Adults

Maree RD, Marcum ZA, Saghafi E, Weiner DK, Karp JF. Am J Geriatr Psychiatry. 2016;24:949-963.

Challenges of the pharmacological management of benzodiazepine withdrawal, dependence, and discontinuation

Fluyau D, Revadigar N, Manobianco BE. Ther Adv Psychopharmacol. 2018;8(5):147-168.

GABAA receptor subtypes and benzodiazepine use, misuse, and abuse

Engin E. Front Psychiatry. 2023;13:1060949.

Benzodiazepine Misuse in the Elderly: Risk Factors, Consequences, and Management

Airagnes G, Pelissolo A, Lavallée M, Flament M, Limosin F. Curr Psychiatry Rep. 2016;18:89.

Benzodiazepines: Uses, Dangers, and Clinical Considerations

Edinoff AN, Nix CA, Hollier J, Sagrera CE, Delacroix BM, Abubakar T, et al. Neurol Int. 2021;13:594-607.

The epidemiology of benzodiazepine misuse: A systematic review

Votaw VR, Geyer R, Rieselbach MM, McHugh RK. Drug Alcohol Depend. 2019;200:95-114.

Challenges of the pharmacological management of benzodiazepine withdrawal, dependence, and discontinuation

Fluyau D, Revadigar N, Manobianco BE. Ther Adv Psychopharmacol. 2018;8(5):147-168.

Benzodiazepines and Related Sedatives

Peng L, Morford KL, Levander XA. Med Clin North Am. 2022;106:113-129.

CME Certificate

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